Description

Z-Leu-Leu-Tyr-A-Keto Aldehyde is a potent and selective proteasome inhibitor, specifically targeting the chymotrypsin-like activity. This compound is a critical research tool for studying proteasome function, ubiquitin-proteasome pathway signaling, and protein degradation mechanisms in cellular systems. It is primarily utilized by researchers in biochemistry, molecular biology, and pharmaceutical development for investigating disease models related to cancer, inflammation, and neurodegenerative disorders.

Application

• Biochemical Research: A key reagent for in vitro and cell-based assays to study proteasome inhibition kinetics and specificity.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in screening programs for novel proteasome-targeting therapeutics.
• Cancer Research: Employed to induce apoptosis and study cell cycle arrest in various cancer cell lines, aiding in mechanistic studies of oncogenesis.
• Neurodegenerative Disease Studies: Applied in models of diseases like Alzheimer's and Parkinson's to understand the role of protein aggregation and clearance.
• Inflammation & Immunology: Used to investigate the role of the proteasome in NF-κB signaling and immune response regulation.
• Enzyme Mechanism Studies: Serves as a substrate analog for detailed enzymatic studies of proteasome active sites.

Basic Information

Product Name	Z-Leu-Leu-Tyr-A-Keto Aldehyde
CAS No.	204649-66-1
Molecular Formula	C30H39N3O7
Molecular Weight	553.65 g/mol
Synonyms	Z-LLY-CHO; Z-Leu-Leu-Tyr-CHO; Carbobenzoxy-Leu-Leu-Tyr-al; N-[(Benzyloxy)carbonyl]-L-leucyl-L-leucyl-L-tyrosinal; Proteasome Inhibitor I; MG-101; Calpain Inhibitor I; N-CBZ-Leu-Leu-Tyr-aldehyde; Acetaldehyde, 2-[[(benzyloxy)carbonyl]-L-leucyl-L-leucyl]amino]-3-(4-hydroxyphenyl)-
EINECS	Contact for details

Quality Control

Our Z-Leu-Leu-Tyr-A-Keto Aldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.