Description

L-Asparagine-n-Fmoc, n-β-Trityl (15N2) is a stable isotope-labeled, orthogonally protected derivative of the amino acid L-asparagine, specifically designed for advanced peptide synthesis and research. This compound is essential for applications requiring precise isotopic labeling, such as in Nuclear Magnetic Resonance (NMR) spectroscopy and mass spectrometry-based proteomics, where it provides critical structural and metabolic insights. It is primarily utilized by pharmaceutical researchers, biochemists, and contract research organizations (CROs) engaged in the development of peptide-based therapeutics, metabolic pathway studies, and high-end analytical method development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of 15N-labeled L-asparagine into synthetic peptides, enabling advanced structural studies.
• NMR Spectroscopy Studies: Used as a tracer in metabolic research and for determining protein structure, dynamics, and interactions through isotopic enrichment.
• Mass Spectrometry & Proteomics: Serves as an internal standard or labeled precursor for quantitative proteomic analysis and metabolic flux studies.
• Bioconjugation & Chemical Biology: The orthogonal Fmoc and Trityl protecting groups allow for selective deprotection, facilitating site-specific modifications in complex biomolecules.
• Research into Neurotransmitters & Metabolism: Applied in neurological and metabolic research due to the role of asparagine in biosynthetic pathways.
• Development of Diagnostic Agents: Potential use in creating isotopically labeled probes for medical imaging and diagnostic assays.

Basic Information

Item	Detail
Product Name	L-Asparagine-n-Fmoc, n-β-Trityl (15N2)
CAS No.	204633-98-7
Molecular Formula	C38H3215N2O5
Molecular Weight	Contact for details
Synonyms	Fmoc-Asn(Trt)-OH (15N2); Nα-Fmoc-Nβ-trityl-L-asparagine-15N2; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-[(triphenylmethyl)amino]-3-oxo-15N2-propanoic acid; Fmoc-L-Asn(Trt)-OH-15N2; Nα-(9-Fluorenylmethyloxycarbonyl)-Nβ-trityl-L-asparagine-15N2; L-Asparagine-15N2, Nα-Fmoc-Nβ-trityl-; Fmoc-Asn(Trt)-15N2-OH
EINECS	Contact for details

Quality Control

Our L-Asparagine-n-Fmoc, n-β-Trityl (15N2) is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity, chemical purity, and chiral integrity. We adhere to relevant industry standards for fine chemicals and advanced research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom %
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.