Description

L-Glutamine-15N2 is a stable isotope-labeled analog of the essential amino acid L-glutamine, where two nitrogen atoms are replaced by the 15N isotope. This product is critical for advanced research applications requiring precise metabolic tracing and quantification, such as in mass spectrometry and nuclear magnetic resonance (NMR) studies. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic companies engaged in proteomics, metabolomics, and pharmacokinetic research.

Application

• Metabolic Pathway Analysis: Used as a tracer in in vitro and in vivo studies to elucidate glutamine metabolism in cancer cells, immune cells, and other biological systems.
• Quantitative Proteomics & Metabolomics: Serves as an internal standard for the accurate mass spectrometric quantification of glutamine and its metabolites in complex biological samples.
• Drug Development & Pharmacokinetics (PK): Employed in preclinical studies to track the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities.
• NMR Spectroscopy: Provides a non-radioactive, stable isotope label for structural and dynamic studies of proteins, peptides, and metabolic fluxes.
• Nutritional Research: Applied in studies investigating amino acid turnover, protein synthesis, and the role of glutamine in clinical nutrition and exercise physiology.
• Diagnostic Assay Development: Used in the calibration and validation of clinical mass spectrometry assays for metabolic disorders.

Basic Information

Product Name	L-Glutamine-15N2
CAS No.	204451-48-9
Molecular Formula	C5H1015N2O3
Molecular Weight	149.12 g/mol (for 15N2 labeled form)
Synonyms	(2S)-2-Amino-4-carbamoylbutanoic-15N2 acid; L-Glutamine (amide-15N2); Glutamine-15N2; (S)-2,5-Diamino-5-oxopentanoic-15N2 acid; Levoglutamide-15N2; 15N Labeled L-Glutamine; L-Gln-15N2; Stable Isotope Labeled Glutamine
EINECS	Contact for details

Quality Control

Our L-Glutamine-15N2 is manufactured under controlled conditions to ensure the highest isotopic and chemical purity for research applications. Each batch undergoes rigorous analytical testing, including HPLC for chemical purity, NMR and/or MS for isotopic enrichment verification, and specific tests for optical rotation and residual solvents. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for assay, isotopic purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 15N
Optical Rotation	+6.3° to +7.3° (c=2 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.