Description

Fmoc-L-4-Hydroxymethyl(Tbu)-Phenylalanine is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound matters because it provides a strategically protected side-chain hydroxyl group, enabling the precise construction of complex peptides with specific post-translational modifications. Pharmaceutical researchers and fine chemical manufacturers need it for developing novel therapeutic peptides, peptidomimetics, and as a key building block in combinatorial chemistry libraries.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the Fmoc/t-Bu strategy, allowing for the controlled incorporation of modified phenylalanine residues.
• Therapeutic Peptide Development: Used in the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Design: Serves as a scaffold for creating stable, bioavailable molecules that mimic natural peptides.
• Combinatorial Chemistry: A valuable component in generating diverse chemical libraries for high-throughput screening and drug discovery.
• Bioconjugation and Labeling: The protected hydroxyl group can be deprotected and functionalized for attaching probes, tags, or linkers.
• Academic and Industrial Research: Fundamental research tool in biochemistry and medicinal chemistry for studying protein structure-function relationships.

Basic Information

Product Name	Fmoc-L-4-Hydroxymethyl(Tbu)-Phenylalanine
CAS No.	204384-68-9
Molecular Formula	C30H33NO6
Molecular Weight	503.59 g/mol
Synonyms	Fmoc-L-4-(tert-Butoxycarbonyloxymethyl)phenylalanine; Fmoc-Tyr(2,6-Cl2Bzl)-OH (common search alias); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-[[(1,1-dimethylethoxy)carbonyl]oxy]methyl]-L-phenylalanine; Fmoc-L-4-Hydroxymethyl(t-butyl)-Phenylalanine; Fmoc-Phe(4-CH2OCOOtBu)-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxycarbonyloxymethyl]phenyl]propanoic acid; Fmoc-L-4-(Boc-oxymethyl)Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-4-Hydroxymethyl(Tbu)-Phenylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We support compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.