Description

Fmoc-D-Homoleucine CAS NO 204320-60-5 is a high-purity, non-natural amino acid derivative featuring the fluorenylmethyloxycarbonyl (Fmoc) protecting group on the D-isomer of homoleucine. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides with specific stereochemistry. It is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research who require high-fidelity, chiral intermediates for creating novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected amino acid, it is used in the Fmoc-strategy for the sequential construction of custom peptide sequences.
• Pharmaceutical Research & Development: Serves as a key intermediate in the synthesis of peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Probe Development: Used to incorporate the D-homoleucine residue into bioactive molecules for studying protein-protein interactions or creating stable labeled peptides.
• Combinatorial Chemistry Libraries: Employed to generate diverse libraries of peptides for high-throughput screening against biological targets.
• Academic & Institutional Research: A fundamental reagent for studies in organic chemistry, medicinal chemistry, and structural biology focused on peptide structure-activity relationships.

Basic Information

Product Name	Fmoc-D-Homoleucine
CAS No.	204320-60-5
Molecular Formula	C₂₂H₂₅NO₄
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-D-hLeu-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-methylhexanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homoleucine; D-2-Amino-4-methylhexanoic acid N-Fmoc derivative; Fmoc-D-2-amino-4-methylhexanoate; N-Fmoc-D-homoleucine; Fmoc-D-HomoLeu
EINECS	Contact for details

Quality Control

Our Fmoc-D-Homoleucine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material suitable for use under cGMP guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.