Description

Boc-Leu-(R)-Phe-Oh is a protected dipeptide building block widely used in solid-phase peptide synthesis (SPPS). This compound is crucial for the controlled assembly of complex peptides, offering precise stereochemistry and protecting group strategy. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Pharmaceutical Intermediates: A key raw material in the synthesis of active pharmaceutical ingredients (APIs) for peptide drugs.
• Peptide Research: Essential building block for academic and industrial research into novel peptide structures and functions.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.
• Bioconjugation: Serves as a linker or spacer in the creation of peptide-protein or peptide-small molecule conjugates.
• Process Development: Employed in scaling up and optimizing synthetic routes for peptide manufacturing.

Basic Information

Product Name	Boc-Leu-(R)-Phe-Oh
CAS No.	204199-69-9
Molecular Formula	C₂₁H₃₂N₂O₅
Molecular Weight	392.49 g/mol
Synonyms	Boc-L-Leu-D-Phe-OH; (2R)-2-[[(2S)-4-Methyl-1-oxo-1-[(2-methylpropan-2-yl)oxycarbonylamino]pentan-2-yl]amino]-3-phenylpropanoic acid; tert-Butyloxycarbonyl-L-leucyl-D-phenylalanine; Boc-L-leucyl-D-phenylalanine; N-(tert-Butoxycarbonyl)-L-leucyl-D-phenylalanine; Boc-Leu-D-Phe-OH; N-Boc-L-leucyl-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-Leu-(R)-Phe-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-Phe)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.