Description

Ethyl 3-Chloro-2-Fluoro-3-Oxopropanoate is a high-purity fluorinated and chlorinated building block essential for advanced organic synthesis. This compound matters because it serves as a versatile precursor for introducing complex halogenated motifs into target molecules, enabling the development of novel agrochemicals and pharmaceuticals. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used as a building block for novel herbicides and fungicides, leveraging the biological activity of the chloro-fluoro substitution pattern.
• Material Science Precursor: Employed in the development of specialty polymers and liquid crystals where halogen atoms modify electronic and physical properties.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial labs for studying the effects of adjacent chlorine and fluorine atoms on reactivity and stability.
• Peptidomimetic Scaffolds: Used to incorporate halogenated keto-ester functionalities into peptide analogs to enhance metabolic stability and binding affinity.

Basic Information

Product Name	Ethyl 3-Chloro-2-Fluoro-3-Oxopropanoate
CAS No.	204136-24-3
Molecular Formula	C5H6ClFO3
Molecular Weight	168.55 g/mol
Synonyms	Ethyl 3-Chloro-2-fluoromalonate; 3-Chloro-2-fluoro-3-oxopropanoic acid ethyl ester; Ethyl 3-chloro-2-fluoromalonate; 2-Fluoro-3-chloro-3-oxopropanoic acid ethyl ester; Ethyl 2-fluoro-3-chloro-3-oxopropanoate; Propanedioic acid, 3-chloro-2-fluoro-, 1-ethyl ester; Ethyl chlorofluoromalonate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Chloro-2-Fluoro-3-Oxopropanoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.