Description

(S)-Fmoc-Beta2-Homovaline CAS NO 203854-59-5 is a high-purity, non-proteinogenic amino acid derivative specifically engineered for advanced peptide synthesis. This compound is critical for introducing the unique steric and electronic properties of the beta2-homovaline side chain into peptide sequences under Fmoc solid-phase peptide synthesis (SPPS) protocols. It is an essential building block for pharmaceutical researchers and peptide chemists developing novel therapeutic peptides, peptidomimetics, and bioactive probes where precise structural control is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, enabling the controlled incorporation of beta2-homovaline into complex peptide chains.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based therapeutics, including hormone analogs, enzyme inhibitors, and receptor ligands.
• Peptidomimetic Design: Serves as a crucial scaffold for creating metabolically stable and bioavailable peptidomimetic drug candidates by modifying backbone geometry.
• Bioconjugation & Probe Development: Facilitates the site-specific introduction of functional handles or labels into peptides for biochemical and diagnostic applications.
• Academic Research: Employed in studies of protein folding, structure-activity relationships (SAR), and the fundamental properties of non-natural amino acids in polypeptides.

Basic Information

Product Name	(S)-Fmoc-Beta2-Homovaline
CAS No.	203854-59-5
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-β2-hVal-OH; (S)-N-(9-Fluorenylmethoxycarbonyl)-3-amino-2-methylbutanoic acid; Fmoc-3-amino-2-methylbutyric acid; Fmoc-beta2-homovaline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-2-methylbutanoic acid; Fmoc-β²-Homovaline; (S)-Fmoc-β²-HVal-OH; Fmoc-L-β²-homovaline
EINECS	Contact for details

Quality Control

Our (S)-Fmoc-Beta2-Homovaline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.