Description

Istaroxime CAS NO 203737-93-3 is a novel, dual-action investigational drug candidate belonging to the class of cardiac myosin activators and sodium-potassium ATPase inhibitors. This compound is significant for its potential to improve both systolic and diastolic function in the heart, representing a promising therapeutic approach for acute heart failure. It is primarily required by pharmaceutical research and development organizations, contract manufacturing organizations (CMOs), and academic institutions engaged in advanced cardiovascular drug discovery and preclinical studies.

Application

• Pharmaceutical R&D (Primary Application): Serves as the active pharmaceutical ingredient (API) in investigational new drug (IND) applications and clinical trial materials for acute heart failure.
• Mechanistic & Preclinical Studies: Used in biochemical and pharmacological research to study cardiac contractility, calcium handling, and the mechanisms of heart failure.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation of related drug products.
• Formulation Development: Utilized in the development of various dosage forms, such as injectable solutions, for stability and compatibility testing.

Basic Information

Product Name	Istaroxime
CAS No.	203737-93-3
Molecular Formula	C26H38N2O5
Molecular Weight	458.59 g/mol
Synonyms	PST-2744; (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione; 3-[(2-Aminoethoxy)imino]-5α-androstane-6,17-dione; (5α,17β)-3-[(2-Aminoethoxy)imino]androstane-6,17-dione; Istaroxime Hydrochloride (salt form); PST2744; UNII-7Q0K7179Y4
EINECS	Contact for details

Quality Control

Our Istaroxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR, MS), purity determination by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements for pharmaceutical research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.