Description

Olprinone is a selective phosphodiesterase III (PDE III) inhibitor used as a potent cardiotonic and vasodilator agent. Its primary value lies in its ability to increase cardiac output and reduce systemic vascular resistance, making it a critical compound for cardiovascular research and pharmaceutical development. This product is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing treatments for acute heart failure and related cardiovascular conditions. We supply high-purity Olprinone to support global R&D and production needs.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable formulations for the treatment of acute decompensated heart failure.
• Cardiovascular Research: A key reference standard and tool compound for studying PDE III inhibition, cardiac contractility, and hemodynamics in preclinical models.
• Drug Discovery & Development: Serves as a lead compound or comparator in the development of new inotropic and vasodilatory therapies.
• Analytical Standard: Used in quality control laboratories as a high-purity reference material for HPLC, LC-MS, and other analytical method development and validation.
• Biochemical Assays: Employed in enzymatic assays to study the mechanism and kinetics of phosphodiesterase inhibition.
• Metabolite Studies: Used in the synthesis and identification of Olprinone metabolites for pharmacokinetic and toxicological profiling.

Basic Information

Product Name	Olprinone
CAS No.	106730-54-5
Molecular Formula	C₁₄H₁₀N₄O₂
Molecular Weight	266.26 g/mol
Synonyms	1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile; E-1020; Olprinone Hydrochloride (salt form); 6-Methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-1,2-dihydropyridine-3-carbonitrile; PDE III Inhibitor E1020; 5-(Imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our Olprinone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to current industry best practices, and our quality systems support the needs of research and development as well as cGMP-compliant pharmaceutical manufacturing. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.