Description

Fmoc-Aib-Opfp CAS NO 203636-26-4 is a specialized, high-purity amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound is critical for introducing the sterically hindered 2-aminoisobutyric acid (Aib) residue into peptide chains, a modification known to induce specific helical conformations and enhance metabolic stability. It is an essential reagent for research and development in pharmaceutical discovery, particularly for creating novel peptide therapeutics, antimicrobial peptides, and peptidomimetics targeting a global market.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester (Opfp), it serves as a crucial coupling reagent for the efficient incorporation of the non-proteinogenic amino acid Aib into growing peptide sequences.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs, where Aib residues are employed to improve bioavailability, proteolytic stability, and conformational control.
• Antimicrobial Peptide (AMP) Design: Facilitates the synthesis of engineered AMPs with enhanced helical structure and potency against resistant bacterial strains.
• Peptidomimetics & Conformation Studies: Enables the synthesis of peptide analogs and foldamers for studying structure-activity relationships and designing bioactive molecules with tailored properties.
• Academic & Institutional Research: A fundamental tool for chemistry and biochemistry departments studying peptide structure, folding, and function.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom peptide synthesis services for clients in the biotech and pharmaceutical industries.

Basic Information

Product Name	Fmoc-Aib-Opfp
CAS No.	203636-26-4
Molecular Formula	C₂₆H₂₀F₅NO₅
Molecular Weight	521.44 g/mol
Synonyms	Fmoc-2-aminoisobutyric acid pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-2-aminoisobutyric acid pentafluorophenyl ester; Fmoc-Aminoisobutyric acid-Opfp ester; Fmoc-Aib-OPfp; Fmoc-α-aminoisobutyric acid pentafluorophenyl ester; N-Fmoc-2-methylalanine pentafluorophenyl ester; (9H-Fluoren-9-yl)methyl (2-((perfluorophenoxy)carbonylamino)-2-methylpropanoate)
EINECS	Contact for details

Quality Control

Our Fmoc-Aib-Opfp is manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, supporting compliance in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.