Description

6-(Piperazin-1-yl)-4-chloropyrimidine is a high-purity, versatile heterocyclic building block of significant importance in modern organic synthesis. Its core value lies in its bifunctional structure, featuring both a reactive chloropyrimidine group and a piperazine moiety, making it an essential intermediate for constructing complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of potential drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced fungicides, herbicides, and plant growth regulators.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized ligands for metal catalysis and coordination chemistry.
• Material Science: A potential precursor for functionalized polymers or organic electronic materials.

Basic Information

Product Name	6-(Piperazin-1-yl)-4-chloropyrimidine
CAS No.	203519-89-5
Molecular Formula	C8H11ClN4
Molecular Weight	198.65 g/mol
Synonyms	4-Chloro-6-(piperazin-1-yl)pyrimidine; 4-Chloro-6-piperazin-1-yl-pyrimidine; 6-(1-Piperazinyl)-4-chloropyrimidine; 4-Chloro-6-piperazinopyrimidine; 203519-89-5; 6-Piperazin-1-yl-4-chloropyrimidine
EINECS	Contact for details

Quality Control

Our 6-(Piperazin-1-yl)-4-chloropyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.