Description

4-(6-Chloro-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine-pyrimidine building block essential for modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of complex molecules, enabling the rapid exploration of structure-activity relationships. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in parallel and combinatorial synthesis for lead optimization and library generation.
• Process Chemistry Development: Serves as a versatile intermediate in the scale-up and route scouting for API manufacturing.
• Chemical Biology Probes: Utilized in the development of tool compounds for target validation and mechanistic studies.
• Agrochemical Research: Potential intermediate in the development of novel crop protection agents.

Basic Information

Product Name	4-(6-Chloro-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	203519-88-4
Molecular Formula	C13H19ClN4O2
Molecular Weight	298.77 g/mol
Synonyms	tert-Butyl 4-(6-chloropyrimidin-4-yl)piperazine-1-carboxylate; 4-(6-Chloro-4-pyrimidinyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-4-(6-chloropyrimidin-4-yl)piperazine; 4-(6-Chloro-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester; 203519-88-4; 4-(6-Chloro-4-pyrimidinyl)-1-piperazinecarboxylic acid tert-butyl ester; Boc-4-(6-chloropyrimidin-4-yl)piperazine
EINECS	Contact for details

Quality Control

Our 4-(6-Chloro-Pyrimidin-4-Yl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) is supplied with each batch, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.