Description

3-Fluoro-4-Chlorobenzyl Alcohol is a versatile fluorinated and chlorinated benzyl alcohol derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in its bifunctional aromatic structure, which allows for selective modifications at both the hydroxyl group and the halogenated benzene ring. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and pesticides, leveraging the fluorine and chlorine atoms for enhanced bioactivity and environmental stability.
• Liquid Crystal Materials: Used in the production of fluorinated liquid crystals for display technologies, where its structure contributes to desired dielectric anisotropy and viscosity.
• Organic Electronic Materials: Serves as a starting material for synthesizing charge-transport materials and emissive layer components in OLEDs and other electronic devices.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Protecting Group Chemistry: The benzyl alcohol moiety can be used to protect other functional groups or can be further derivatized into ethers or esters for specific synthetic pathways.
• Chiral Auxiliary & Ligand Synthesis: Utilized in the preparation of chiral ligands for asymmetric catalysis and as a scaffold for chiral auxiliaries.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process R&D for exploring new chemical spaces and optimizing synthetic routes.

Basic Information

Product Name	3-Fluoro-4-Chlorobenzyl Alcohol
CAS No.	202925-10-8
Molecular Formula	C7H6ClFO
Molecular Weight	160.57 g/mol
Synonyms	(3-Fluoro-4-chlorophenyl)methanol; 4-Chloro-3-fluorobenzyl Alcohol; 1-(Chloromethyl)-2-fluoro-4-chlorobenzene (deprecated); α-Hydroxymethyl-4-chloro-3-fluorobenzene; 3-Fluoro-4-chlorobenzenemethanol; FCBA; 4-Chloro-3-fluoro-benzenemethanol
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Chlorobenzyl Alcohol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical and advanced material applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.