Description

Fmoc-His(1-Me)-Oh CAS NO 202920-22-7 is a protected derivative of the amino acid histidine, specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly when incorporating the unique imidazole side chain of histidine. It is an essential building block for pharmaceutical R&D, biotechnology, and academic laboratories developing therapeutic peptides, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated, stepwise construction of complex peptide sequences.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, hormones, and enzyme inhibitors where histidine's catalytic or metal-binding properties are required.
• Bioconjugation & Probe Development: Used to introduce a selectively protected histidine residue into peptides for subsequent labeling or immobilization studies.
• Combinatorial Chemistry Libraries: Serves as a variable building block in the generation of diverse peptide libraries for high-throughput screening.
• Academic & Biochemical Studies: Fundamental research into protein structure-function relationships, enzyme mechanisms, and peptide self-assembly.

Basic Information

Product Name	Fmoc-His(1-Me)-Oh
CAS No.	202920-22-7
Molecular Formula	C₂₂H₂₃N₃O₅
Molecular Weight	409.44 g/mol
Synonyms	Fmoc-N(π)-methyl-L-histidine; N-α-Fmoc-N(π)-methyl-L-histidine; Fmoc-1-methyl-L-histidine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-3-(1-methyl-1H-imidazol-4-yl)propanoic acid; Fmoc-His(1-Me)-OH; Fmoc-N(π)-Me-His-OH; N-α-(9-Fluorenylmethoxycarbonyl)-N(π)-methyl-L-histidine
EINECS	Contact for details

Quality Control

Our Fmoc-His(1-Me)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material suitable for research and GMP-grade development work upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -14.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.