Description

H-Trp-Phe-Tyr-Ser(Po3H2)-Pro-Arg-Pna is a synthetic, phosphorylated peptide sequence designed for advanced biochemical research and development. This compound is a critical tool for studying kinase and phosphatase activity, signal transduction pathways, and protein-protein interactions. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on drug discovery, particularly in the fields of oncology, metabolic disorders, and neurological diseases.

Application

• Biochemical Research: Used as a specific substrate for studying the kinetics and inhibition profiles of serine/threonine kinases and their corresponding phosphatases.
• Drug Discovery Screening: Serves as a key component in high-throughput screening (HTS) assays to identify novel kinase inhibitors or activators for therapeutic development.
• Enzyme Characterization: Employed to determine the specificity and catalytic efficiency of phospho-specific antibodies or binding domains in vitro.
• Signal Transduction Studies: Facilitates the investigation of intracellular signaling cascades by mimicking native phosphorylated peptide motifs.
• Diagnostic Development: Can be used in the development of ELISA or other immunoassays to detect kinase activity in clinical samples.
• Peptide Library Synthesis: Acts as a reference standard or a building block in the synthesis of focused peptide libraries for proteomic studies.

Basic Information

Product Name	H-Trp-Phe-Tyr-Ser(Po3H2)-Pro-Arg-Pna
CAS No.	202739-41-1
Molecular Formula	C53H64N13O13P
Molecular Weight	1130.13 g/mol
Synonyms	H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA; p-Nitroanilide Substrate WFYpSPR-pNA; Phospho-Serine Peptide Substrate; Tryptophan-Phenylalanine-Tyrosine-phosphoSerine-Proline-Arginine-p-nitroanilide; Kinase Substrate Peptide 202739-41-1; WFpYSPR-pNA; pNA-labeled phosphopeptide; Signal Transduction Peptide Inhibitor
EINECS	Contact for details

Quality Control

Our H-Trp-Phe-Tyr-Ser(Po3H2)-Pro-Arg-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA) to ensure structural integrity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.