Description

L-Aspartic Acid-13C4,15N is a stable isotope-labeled analog of the essential amino acid L-aspartic acid, where all four carbon atoms are the 13C isotope and the nitrogen atom is the 15N isotope. This high-purity labeled compound is critical for advanced analytical research, enabling precise metabolic pathway tracing and quantitative proteomic analysis. It is an indispensable tool for scientists in pharmaceutical development, nutritional studies, and biomedical research who require the highest standards of isotopic enrichment and chemical purity for accurate mass spectrometry and NMR applications.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous aspartic acid levels in complex biological matrices.
• Metabolic Flux Analysis (MFA): Serves as a tracer to study the dynamics of central carbon and nitrogen metabolism in cell cultures, tissues, and whole organisms.
• Proteomics & Protein Turnover Studies: Incorporated into proteins via cell culture (SILAC) or in vivo labeling to measure protein synthesis and degradation rates.
• NMR Spectroscopy: Provides a non-radioactive, sensitive probe for elucidating molecular structures and reaction mechanisms in biochemical research.
• Pharmaceutical Drug Metabolism & Pharmacokinetics (DMPK): Employed in the development and validation of bioanalytical methods for tracking drug metabolites.
• Nutritional Research: Used to investigate amino acid absorption, utilization, and whole-body protein metabolism in clinical and preclinical studies.

Basic Information

Product Name	L-Aspartic Acid-13C4,15N
CAS No.	202468-27-7
Molecular Formula	¹³C₄H₇¹⁵NO₄
Molecular Weight	136.06 (based on ¹³C=13.0034, ¹⁵N=15.0001)
Synonyms	(2S)-2-Aminobutanedioic acid-13C4,15N; L-Aminosuccinic acid-13C4,15N; Aspartic acid-13C4,15N (L-form); (S)-Aminobutanedioic acid-13C4,15N; 13C4,15N-L-Asp; 13C4,15N-L-Aspartic Acid; Stable Isotope Labeled L-Aspartic Acid; L-Asp-13C4,15N
EINECS	Contact for details

Quality Control

Our L-Aspartic Acid-13C4,15N is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, critical for sensitive research applications. Each batch is comprehensively analyzed using advanced techniques including NMR, HPLC, and mass spectrometry to confirm identity, isotopic enrichment (>99% atom ¹³C and ¹⁵N), and chemical purity. A detailed Certificate of Analysis (COA) is provided, documenting all specifications and test results to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and weighing accuracy. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (¹³C)	≥ 99 atom %
Isotopic Enrichment (¹⁵N)	≥ 99 atom %
Chemical Purity	≥ 98.0%
Optical Rotation	[α]²⁰D = +24.5° to +26.0° (c=1 in 6N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.