Description

(S)-Rasagiline Mesylate CAS NO 202464-88-8 is a high-purity, enantiomerically pure active pharmaceutical ingredient (API) and key chiral intermediate. It is the active enantiomer of the selective, irreversible monoamine oxidase-B (MAO-B) inhibitor used in the treatment of Parkinson's disease. This compound is essential for pharmaceutical R&D, process development, and the commercial manufacturing of advanced neurological therapeutics. Its consistent quality and reliable supply are critical for ensuring the efficacy and safety of final drug products.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active moiety in the synthesis of Rasagiline mesylate, a medication for Parkinson's disease.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Process Chemistry & R&D: A crucial chiral building block for research into novel MAO-B inhibitors and other neurological agents.
• Generic Drug Manufacturing: Key starting material (KSM) or intermediate in the production of generic versions of Rasagiline-based medications.
• Biochemical Research: Used in in-vitro and in-vivo studies to investigate MAO-B enzyme kinetics and neuroprotective mechanisms.
• Formulation Development: Employed in pre-formulation and formulation studies for various dosage forms, such as tablets.

Basic Information

Product Name	(S)-Rasagiline Mesylate
CAS No.	202464-88-8
Molecular Formula	C12H13N • CH4O3S
Molecular Weight	267.35 g/mol
Synonyms	(1R)-N-(2-Propyn-1-yl)-2,3-dihydro-1H-inden-1-amine methanesulfonate; (R)-N-2-Propynyl-1-indanamine mesylate; (R)-N-Propargyl-1-aminoindan mesylate; AGN 1135; TVP 1012; Rasagiline mesylate (S-enantiomer); (S)-Rasagiline methanesulfonate
EINECS	Contact for details

Quality Control

Our (S)-Rasagiline Mesylate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and enantiomeric excess, aligning with ICH guidelines for pharmaceutical ingredients. Comprehensive testing includes HPLC for assay and related substances, chiral purity determination, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.