Description

L-Alanine-13C3,15N is a stable isotope-labeled analog of the essential amino acid L-Alanine, where all three carbon atoms are the 13C isotope and the nitrogen atom is the 15N isotope. This high-purity labeled compound is critical for advanced research requiring precise metabolic and proteomic pathway tracing. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications in Nuclear Magnetic Resonance (NMR) spectroscopy, Mass Spectrometry (MS), and metabolic flux analysis.

Application

• Metabolic Research & Flux Analysis: As a tracer to study amino acid metabolism, protein synthesis rates, and metabolic pathways in cell cultures, tissues, and whole organisms.
• Proteomics & Biomarker Discovery: Used in quantitative proteomics via techniques like SILAC (Stable Isotope Labeling by Amino acids in Cell culture) for accurate protein quantification and identification.
• NMR Spectroscopy: Serves as an internal standard or enriched substrate to enhance signal resolution and simplify complex spectral interpretation in structural biology and metabolomics.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules and their metabolites.
• Nutritional Science Research: Used to investigate protein turnover, amino acid requirements, and the metabolic effects of dietary components.
• Manufacturing of Labeled Compounds: Acts as a high-purity building block for the synthesis of more complex isotope-labeled peptides, proteins, or pharmaceutical agents.

Basic Information

Product Name	L-Alanine-13C3,15N
CAS No.	202407-38-3
Molecular Formula	¹³C₃H₇¹⁵NO₂
Molecular Weight	92.06 g/mol (for ¹³C₃, ¹⁵N)
Synonyms	(2S)-2-Aminopropanoic-13C3,15N; L-2-Aminopropionic-13C3,15N acid; (S)-Alanine-13C3,15N; Ala-13C3,15N; L-α-Alanine-13C3,15N; Stable Isotope Labeled L-Alanine; 13C3,15N-L-Alanine; ¹³C₃,¹⁵N-L-Alanine
EINECS	Contact for details

Quality Control

Our L-Alanine-13C3,15N is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, essential for sensitive research applications. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic enrichment (atom % 13C and 15N), chemical purity, chiral purity, and results for specific tests. We adhere to cGMP principles where applicable to support preclinical and clinical research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive). Store in a cool, dry place. Keep container tightly sealed in a desiccated environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Isotopic Enrichment (15N)	≥ 98 atom % 15N
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.