Description

n-Butyryl-L-Homocysteine Thiolactone is a specialized, high-purity biochemical building block used in advanced organic synthesis and pharmaceutical research. This compound serves as a key intermediate for the preparation of modified peptides and enzyme inhibitors, offering precise control over molecular structure and function. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics and biochemical probes.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting enzyme pathways related to homocysteine metabolism.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic processes and disease mechanisms.
• Peptide Chemistry: Serves as a protected or activated building block for the solid-phase or solution-phase synthesis of custom peptides with specific thiolactone functionalities.
• Proteomics & Labeling Reagents: Can be utilized to develop chemical probes for protein labeling, interaction studies, and activity-based profiling.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	n-Butyryl-L-Homocysteine Thiolactone
CAS No.	202284-85-3
Molecular Formula	C9H15NO2S
Molecular Weight	201.29 g/mol
Synonyms	L-Homocysteine thiolactone, N-Butyryl derivative; N-Butanoyl-L-homocysteine thiolactone; (S)-2-(Butyrylamino)-4,5-dihydrothiophen-3(2H)-one; Butyrylhomocysteine thiolactone; BHTL; N-Butyrylhomocysteine thiolactone; 2-[(1-Oxobutyl)amino]-4,5-dihydro-3(2H)-thiophenone
EINECS	Contact for details

Quality Control

Our n-Butyryl-L-Homocysteine Thiolactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.