Description

D-Valine-Leucine-Arginine-4-Methoxy-2-Naphthylamine, Trifluoroacetate Salt is a synthetic, protected tripeptide derivative used as a key intermediate in advanced pharmaceutical research and development. This compound is specifically engineered for applications requiring high-purity, sequence-specific peptide building blocks. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic peptides, protease substrates, and biochemical probes.

Application

• Pharmaceutical Intermediate: Critical building block for the solid-phase or solution-phase synthesis of complex peptide-based drug candidates.
• Protease Research: Serves as a specialized substrate or inhibitor scaffold for studying enzyme kinetics and mechanisms of proteolytic enzymes like trypsin and related serine proteases.
• Biochemical Tool Development: Used in the design and creation of fluorogenic or chromogenic assay reagents, leveraging the 4-Methoxy-2-Naphthylamine (4M2NA) moiety.
• Peptide Library Synthesis: A valuable component for generating focused libraries in drug discovery to screen for biological activity and optimize peptide sequences.
• Standards and Reference Materials: Provides a high-purity standard for analytical method development and quality control in peptide manufacturing.

Basic Information

Product Name	D-Valine-Leucine-Arginine-4-Methoxy-2-Naphthylamine, Trifluoroacetate Salt
CAS No.	201982-93-6
Molecular Formula	C32H51F3N8O7
Molecular Weight	716.80 g/mol
Synonyms	D-Val-Leu-Arg-4-Methoxy-2-Naphthylamine TFA Salt; H-D-Val-Leu-Arg-4M2NA TFA; D-Valyl-L-leucyl-L-arginyl-4-methoxy-2-naphthylamide trifluoroacetate; Fluorogenic Peptide Substrate VLR-4M2NA; Protease Substrate VLR-4M2NA TFA; D-Val-Leu-Arg-4MNA TFA Salt; Trypsin Substrate Analog; (2S)-2-[[(2S)-2-[[(2R)-2-Amino-3-methyl-butanoyl]amino]-4-methyl-pentanoyl]amino]-5-(diaminomethylideneamino)-N-(4-methoxy-2-naphthyl)pentanamide;2,2,2-trifluoroacetate
EINECS	Contact for details

Quality Control

Our D-Valine-Leucine-Arginine-4-Methoxy-2-Naphthylamine, Trifluoroacetate Salt is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.