Description

H-Phe-Leu-Phe-4Mβna · Tfa is a synthetic peptide substrate designed for enzymatic activity studies, specifically for proteases like cathepsin D and renin. This compound matters for researchers and manufacturers requiring precise, high-purity biochemical tools to study enzyme kinetics, inhibition, and substrate specificity. It is primarily needed by pharmaceutical R&D teams, diagnostic kit developers, and academic biochemistry laboratories focused on protease-related disease mechanisms and drug discovery.

Application

• As a fluorogenic substrate for kinetic assays of aspartic proteases, including cathepsin D.
• In high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors for therapeutic development.
• For biochemical research into enzyme mechanisms, substrate specificity, and proteolytic pathways.
• In the development and quality control of diagnostic assays targeting specific protease activities.
• As a critical reagent in pharmaceutical R&D for studying conditions like cancer, neurodegenerative diseases, and hypertension where proteases play a key role.

Basic Information

Product Name	H-Phe-Leu-Phe-4Mβna · Tfa
CAS No.	201982-86-7
Molecular Formula	C36H41F3N4O7
Molecular Weight	698.73 g/mol
Synonyms	H-Phe-Leu-Phe-4-Methoxy-β-naphthylamide Trifluoroacetate; Phe-Leu-Phe-4MβNA TFA; Cathepsin D Substrate IV; Fluorogenic Substrate for Cathepsin D; Aspartic Protease Substrate; H-Phenylalanyl-L-leucyl-L-phenylalanyl-4-methoxy-2-naphthylamide TFA Salt; Renin Substrate Analog; 4-Methoxy-2-naphthylamide derivative of Phe-Leu-Phe
EINECS	Contact for details

Quality Control

Our H-Phe-Leu-Phe-4Mβna · Tfa is manufactured under strict quality protocols to ensure batch-to-batch consistency and high biochemical performance. Each lot is characterized by advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.