Description

Bz-Arg-Gly-Phe-Phe-Pro-4Mβna · Hcl is a synthetic peptide substrate designed for high-precision biochemical research and diagnostic applications. This compound is critical for studying and quantifying the activity of specific proteolytic enzymes, such as furin and other proprotein convertases, due to its optimized cleavage sequence. It is an essential reagent for pharmaceutical R&D, academic research, and the development of enzyme-linked assays in clinical diagnostics.

Application

• Enzyme Kinetics & Inhibition Studies: Primary substrate for measuring the kinetic parameters and inhibitory profiles of serine proteases and proprotein convertases.
• Pharmaceutical Screening: Used in high-throughput screening (HTS) assays to identify and characterize novel therapeutic enzyme inhibitors for diseases like cancer and viral infections.
• Diagnostic Assay Development: Key component in the formulation of chromogenic or fluorogenic assay kits for clinical and research laboratory use.
• Biochemical Research: Fundamental tool for investigating protease specificity, activation pathways, and regulatory mechanisms in cellular processes.
• Quality Control in Biologics: Employed in QC labs to monitor and validate the activity and consistency of enzyme-based biopharmaceutical products.

Basic Information

Product Name	Bz-Arg-Gly-Phe-Phe-Pro-4Mβna · Hcl
CAS No.	201928-98-5
Molecular Formula	C48H58N12O8 · HCl
Molecular Weight	~967.5 g/mol
Synonyms	Benzoyl-Arg-Gly-Phe-Phe-Pro-4-Methoxy-β-Naphthylamide Hydrochloride; Bz-R-G-F-F-P-4MβNA·HCl; Furin Substrate; Boc-RVRR-AMC (related analog); Proprotein Convertase Substrate; Peptide-4-Methoxy-2-Naphthylamide; Chromogenic Peptide Substrate; Fluorogenic Peptide Derivative
EINECS	Contact for details

Quality Control

Every batch of Bz-Arg-Gly-Phe-Phe-Pro-4Mβna · Hcl is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and performance consistency. Our quality system is designed to meet the stringent requirements of research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity confirmation, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 70.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water/methanol mixtures
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.