Description

H-D-Glu(Amc)-Oh CAS NO 201851-56-1 is a protected glutamic acid derivative, specifically the H-D-Glu(Amc)-OH form, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity, stereochemically defined amino acid derivatives to ensure the integrity of complex peptide sequences. It is primarily utilized by the pharmaceutical, biotechnology, and advanced chemical research sectors for developing therapeutic peptides, diagnostic agents, and novel biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled elongation of peptide chains, particularly where glutamic acid side-chain protection is required.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation & Labeling: Used in the preparation of peptide conjugates for targeted drug delivery, imaging probes, and antibody-drug conjugates (ADCs).
• Biochemical Research: Employed in enzymatic studies, substrate preparation, and the synthesis of custom peptides for structure-activity relationship (SAR) studies.
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to discover new bioactive molecules.

Basic Information

Product Name	H-D-Glu(Amc)-Oh
CAS No.	201851-56-1
Molecular Formula	C₁₃H₁₄N₂O₅
Molecular Weight	278.26 g/mol
Synonyms	H-D-Glu(AMC)-OH; Fmoc-D-Glu(Amc)-OH; D-Glutamic acid α-amide, γ-7-amido-4-methylcoumarin; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-[(7-amino-4-methyl-2-oxo-2H-chromen-1-yl)amino]-5-oxopentanoic acid; D-Glu(Amc)-OH; Protected D-Glutamic Acid Amc derivative; 7-Amido-4-methylcoumarin-D-Glutamic acid derivative; Peptide synthesis building block Fmoc-D-Glu(Amc)-OH
EINECS	Contact for details

Quality Control

Our H-D-Glu(Amc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.