Description

H-Thr(Tbu)-Pna is a protected amino acid derivative, specifically an N-terminal Boc-protected threonine para-nitroanilide. This compound serves as a crucial building block and synthetic intermediate in advanced organic and peptide chemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutic agents and biochemical tools.

Application

• Peptide Synthesis: As a key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Research: For the development and screening of protease inhibitors and other enzyme-targeted drugs.
• Biochemical Reagent: Used in enzymatic assays as a chromogenic substrate for studying protease activity and kinetics.
• Chemical Biology: Employed in the synthesis of activity-based probes (ABPs) for profiling enzyme function.
• Academic Research: A valuable reagent for synthetic organic chemistry studies and methodology development.
• Custom Synthesis: Serves as a starting material for the custom synthesis of complex peptides and peptide mimetics.

Basic Information

Product Name	H-Thr(Tbu)-Pna
CAS No.	201807-08-1
Molecular Formula	C₁₅H₂₁N₃O₅
Molecular Weight	323.35 g/mol
Synonyms	Boc-Thr(Tbu)-pNA; Boc-L-Threonine(t-butyl)-4-nitroanilide; N-(tert-Butoxycarbonyl)-O-tert-butyl-L-threonine 4-nitroanilide; (2S,3R)-2-[(tert-Butoxycarbonyl)amino]-3-[(2-methylpropan-2-yl)oxy]butanoic acid 4-nitroanilide; Boc-Thr(OtBu)-pNA; H-Thr(OtBu)-Pna; Boc-Threonine(OtBu)-pNA; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-O-(1,1-dimethylethyl)-, 4-nitroanilide
EINECS	Contact for details

Quality Control

Our H-Thr(Tbu)-Pna is manufactured under strict quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets exacting standards for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	[α]²⁰/D: Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.