Description

n-(tert-Butoxycarbonyl)-L-Alanine-3-13C is a stable isotope-labeled derivative of the amino acid L-alanine, where the carbon at the 3-position is enriched with the carbon-13 isotope. This compound is a critical building block for the synthesis of isotopically labeled peptides and proteins, enabling advanced research in metabolism, proteomics, and pharmacokinetics. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in tracer studies and mass spectrometry-based analytical method development.

Application

• Isotopic Tracer in Metabolic Studies: Used to trace metabolic pathways and flux analysis in biological systems.
• Internal Standard for Mass Spectrometry: Serves as a quantitative internal standard in LC-MS/MS and GC-MS for accurate bioanalysis of peptides and amino acids.
• Synthesis of Labeled Bioactive Peptides: A key protected intermediate for the solid-phase or solution-phase synthesis of carbon-13 labeled peptides for research.
• Proteomics Research: Facilitates protein quantification and turnover studies using stable isotope labeling techniques (SILAC).
• NMR Spectroscopy: Used to incorporate a carbon-13 label into larger molecules for structural elucidation via Nuclear Magnetic Resonance spectroscopy.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for creating isotopically labeled drug candidates to study absorption, distribution, metabolism, and excretion (ADME).

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-L-Alanine-3-13C
CAS No.	201740-79-6
Molecular Formula	C8H1513CNO4
Molecular Weight	190.20 g/mol (for 13C labeled form)
Synonyms	Boc-L-Alanine-3-13C; (2S)-2-[(tert-Butoxycarbonyl)amino]propanoic-3-13C acid; N-Boc-L-alanine-3-13C; tert-Butoxycarbonyl-L-alanine-3-13C; Boc-Ala-3-13C-OH; (S)-2-((tert-Butoxycarbonyl)amino)propionic-3-13C acid; L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, 3-13C; BOC-L-ALA-3-13C
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-L-Alanine-3-13C is manufactured under strict quality control protocols to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay (by HPLC), isotopic enrichment, chiral purity, and impurity profile. We adhere to cGMP principles for pharmaceutical intermediates, and our quality system is designed to meet the stringent requirements of research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.