Description

Meosuc-Val-Val-Ile-Ala-Pna CAS NO 201737-55-5 is a specialized synthetic peptide derivative, specifically a tetrapeptide sequence modified with a mesyl (Meosuc) group and a p-nitroanilide (Pna) moiety. This compound is of significant value in biochemical and pharmaceutical research as a highly specific and sensitive substrate for studying the activity and inhibition of proteolytic enzymes, particularly elastases and related serine proteases. It is primarily needed by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on inflammation, pulmonary diseases, and protease inhibitor development.

Application

• Enzyme Activity Assays: As a chromogenic substrate for the quantitative determination of human leukocyte elastase (HLE) and pancreatic elastase activity in research settings.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify and characterize novel elastase inhibitors for therapeutic applications.
• Biochemical Research: Employed in kinetic studies to elucidate the mechanism of action, specificity, and catalytic efficiency of various serine proteases.
• Diagnostic Development: Serves as a key component in developing in vitro diagnostic (IVD) tests for conditions associated with elevated elastase levels, such as chronic obstructive pulmonary disease (COPD) and pancreatitis.
• Quality Control in Biologics: Used to monitor the presence and activity of specific proteases during the manufacturing and purification processes of biopharmaceuticals.

Basic Information

Product Name	Meosuc-Val-Val-Ile-Ala-Pna
CAS No.	201737-55-5
Molecular Formula	C30H46N6O9S
Molecular Weight	666.79 g/mol
Synonyms	N-Methoxysuccinyl-Val-Val-Ile-Ala-p-Nitroanilide; MeOSuc-VVIA-pNA; Methoxysuccinyl-Alanyl-Prolyl-Valine p-Nitroanilide (related); Elastase Substrate IV; HLE Substrate; Suc(OMe)-Val-Val-Ile-Ala-pNA; Protease Substrate for Human Leukocyte Elastase; N-(Methoxycarbonyl)succinyl-Val-Val-Ile-Ala-4-nitroanilide
EINECS	Contact for details

Quality Control

Our Meosuc-Val-Val-Ile-Ala-Pna is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. Certificates of Analysis (COA) detailing purity, assay, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.