Description

Fmoc-S-Trityl-L-Penicillamine CAS NO 201531-88-6 is a protected, non-proteinogenic amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide chain assembly, particularly when incorporating the unique structural features of penicillamine. It is an essential building block for pharmaceutical R&D, enabling the synthesis of complex peptides and peptidomimetics for therapeutic applications in drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, used in the automated synthesis of complex peptides.
• Pharmaceutical Research & Development: Serves as a crucial intermediate in the discovery and development of novel peptide-based therapeutics and drug candidates.
• Peptidomimetic Design: Used to incorporate the constrained, thiol-containing penicillamine scaffold into designed molecules that mimic natural peptides.
• Bioconjugation and Labeling: The protected thiol group (S-Trityl) allows for selective deprotection and subsequent conjugation with labels, tags, or other biomolecules.
• Chemical Biology Probes: Employed in the synthesis of specialized probes for studying enzyme mechanisms, protein-protein interactions, and cellular processes.
• Academic and Institutional Research: A fundamental reagent for laboratories focused on organic synthesis, medicinal chemistry, and peptide science.

Basic Information

Product Name	Fmoc-S-Trityl-L-Penicillamine
CAS No.	201531-88-6
Molecular Formula	C39H35NO4S
Molecular Weight	613.76 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-penicillamine; Fmoc-Pen(Strt)-OH; Fmoc-L-Penicillamine(S-Trityl); (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-methyl-3-(tritylsulfanyl)butanoic acid; N-Fmoc-S-trityl-L-penicillamine; Fmoc-Pen(Trt)-OH; Fmoc-S-Trt-L-Pen-OH; Fmoc-Cys(Me,Strt)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-S-Trityl-L-Penicillamine is produced under strict quality management protocols to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.