Description

Ethyl 4-(4-Fluorophenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarboxylate is a high-purity, advanced pharmaceutical intermediate with a distinct thioxo-tetrahydropyrimidinecarboxylate core structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for process development and commercial-scale production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those with dihydropyrimidinone (DHPM) scaffolds known for diverse biological activities.
• API Synthesis: Used in the research and production of Active Pharmaceutical Ingredients (APIs) for potential therapeutic areas including neurology and oncology.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and other advanced intermediates.
• Contract Manufacturing (CMO): Supplied to Contract Manufacturing Organizations for cGMP-compliant production of clinical trial materials and commercial drugs.

Basic Information

Product Name	Ethyl 4-(4-Fluorophenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarboxylate
CAS No.	201287-93-6
Molecular Formula	C14H15FN2O2S
Molecular Weight	294.34 g/mol
Synonyms	Ethyl 4-(4-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate; 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(4-fluorophenyl)-6-methyl-2-thioxo-, ethyl ester; Ethyl 4-(p-fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 4-(4-Fluorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylic acid ethyl ester; DHPM derivative; Biginelli reaction product; Fluorophenyl-substituted dihydropyrimidinone.
EINECS	Contact for details

Quality Control

Our Ethyl 4-(4-Fluorophenyl)-6-Methyl-2-Thioxo-1,2,3,4-Tetrahydro-5-Pyrimidinecarboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided and can be tailored to meet specific client or regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.