Description

Z-Orn(Fmoc)-Oh is a protected amino acid derivative, specifically Nδ-Fmoc-L-ornithine, which serves as a critical building block in solid-phase peptide synthesis (SPPS). Its value lies in providing a selectively protected side chain amine, allowing for the controlled and sequential construction of complex peptides and peptidomimetics. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require reliable, high-quality reagents for producing therapeutic peptides, diagnostic agents, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled incorporation of ornithine residues into peptide chains using Fmoc-chemistry protocols.
• Pharmaceutical R&D: Synthesis of novel therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation: Used to introduce reactive amine handles (after deprotection) for linking peptides to dyes, polymers, or other biomolecules.
• Antibiotic Development: Key intermediate in the synthesis of polymyxin and other cyclic lipopeptide antibiotics.
• Chemical Biology Probes: Construction of labeled peptides and activity-based probes for studying enzyme function and protein-protein interactions.
• Material Science: Synthesis of peptide-based polymers and hydrogels with tailored biological and mechanical properties.

Basic Information

Product Name	Z-Orn(Fmoc)-Oh
CAS No.	201048-68-2
Molecular Formula	C22H24N2O6
Molecular Weight	412.44 g/mol
Synonyms	Nδ-Fmoc-Nα-Cbz-L-ornithine; Nα-Carbobenzyloxy-Nδ-(9-fluorenylmethoxycarbonyl)-L-ornithine; Fmoc-Orn(Z)-OH; Nα-Z-Nδ-Fmoc-L-ornithine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((benzyloxy)carbonyl)amino)pentanoic acid; Cbz-Orn(Fmoc)-OH; Z-L-Orn(Fmoc)-OH; Nδ-(9-Fluorenylmethyloxycarbonyl)-Nα-carbobenzyloxy-L-ornithine
EINECS	Contact for details

Quality Control

Our Z-Orn(Fmoc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.