Description

H-D-Lys(Boc)-Otbu Hcl is a protected derivative of the essential amino acid L-lysine, specifically designed for peptide synthesis. This compound is a critical building block in the pharmaceutical and biotechnology industries, enabling the controlled assembly of complex peptide chains. It is primarily utilized by research institutions, CROs/CDMOs, and pharmaceutical companies engaged in the development of therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, facilitating the incorporation of lysine residues.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins in solution.
• Pharmaceutical Intermediates: Serves as a crucial intermediate in the production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation and Labeling: The orthogonal protecting groups (Boc and OtBu) allow for selective deprotection, making it valuable for site-specific modifications and linker attachments.
• Research & Development: Essential for academic and industrial R&D focused on novel peptide structures, hormone analogs, and diagnostic agents.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	H-D-Lys(Boc)-Otbu Hcl
CAS No.	201007-86-5
Molecular Formula	C16H33ClN2O5
Molecular Weight	368.90 g/mol
Synonyms	H-D-Lys(Boc)-Otbu hydrochloride; (2R)-6-{[(2-Methylpropan-2-yl)oxy]carbonylamino}-2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]azanium chloride; Boc-D-Lys(OtBu)-OH · HCl; N6-Boc-Nα-tert-butyloxycarbonyl-D-lysine hydrochloride; D-Lysine, N6-[(1,1-dimethylethoxy)carbonyl]-, 1-(1,1-dimethylethyl) ester, hydrochloride (1:1); Boc-D-Lys(OtBu)-HCl; tert-Butyl N-[(2R)-6-{[(tert-butoxy)carbonyl]amino}-1-hydroxy-1-oxohexan-2-yl]carbamate hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Lys(Boc)-Otbu Hcl is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, supporting applications in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.