Description

N-(9-Fluorenylmethoxycarbonyl)-L-Leucine is a protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and sequential assembly of complex peptides and proteins in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the biotechnology, pharmaceutical, and fine chemical industries for the production of therapeutic peptides, diagnostic agents, and novel biomaterials.

Application

• Key intermediate in solid-phase peptide synthesis (SPPS) using the Fmoc protection strategy.
• Building block for the research and production of therapeutic peptides and peptidomimetics.
• Used in the synthesis of custom peptides for biochemical and pharmacological studies.
• Critical raw material for manufacturing active pharmaceutical ingredients (APIs) in peptide-based drugs.
• Employed in the development of diagnostic reagents and imaging probes.
• Precursor for creating specialized amino acid analogs and conjugated peptides.
• Used in combinatorial chemistry libraries for drug discovery and high-throughput screening.

Basic Information

Product Name	N-(9-Fluorenylmethoxycarbonyl)-L-Leucine
CAS No.	200937-57-1
Molecular Formula	C₂₁H₂₃NO₄
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-L-Leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid; Fmoc-Leu-OH; Fmoc-Leucine; N-Fmoc-L-leucine; L-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-L-Leu
EINECS	Contact for details

Quality Control

Our N-(9-Fluorenylmethoxycarbonyl)-L-Leucine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material meeting specific customer requirements for advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.