Description

Boc-D-Leu-OH·H2O is a protected derivative of the non-essential amino acid D-leucine, featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is a critical chiral building block in the synthesis of peptides and peptidomimetics, offering high enantiomeric purity and stability for complex organic transformations. It is essential for research and production in the pharmaceutical and biotechnology sectors, particularly for developing therapeutic peptides, protease inhibitors, and novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key raw material in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetic drugs.
• Protease Inhibitor Development: Used to incorporate the D-leucine residue into substrates for designing specific enzyme inhibitors.
• Biochemical Research: Serves as a chiral precursor in studying enzyme mechanisms, protein folding, and structure-activity relationships (SAR).
• API Synthesis: Employed in the multi-step synthesis of complex active pharmaceutical ingredients requiring high stereochemical fidelity.
• Custom Peptide Services: A fundamental component for CROs and CDMOs offering bespoke peptide synthesis for clients.
• Material Science: Potential monomer for creating specialized polymers and biomaterials with specific chiral properties.

Basic Information

Item	Detail
Product Name	Boc-D-Leu-OH·H2O
CAS No.	200937-17-3
Molecular Formula	C11H21NO5
Molecular Weight	247.29 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanoic acid hydrate; D-Boc-Leucine hydrate; Boc-D-Leucine monohydrate; N-(tert-Butoxycarbonyl)-D-leucine hydrate; N-Boc-D-leucine hydrate; (R)-N-Boc-leucine hydrate; (R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylpentanoic acid hydrate
EINECS	Contact for details

Quality Control

Our Boc-D-Leu-OH·H2O is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, specific rotation, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Specific Rotation	Contact for details
Water Content (KF)	Theoretical (Hydrate)
Heavy Metals	<10 ppm
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.