Description

D-Histidine(1-Trt)-Ome Hcl is a protected derivative of the essential amino acid D-Histidine, specifically designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, chirally pure building blocks to construct complex bioactive peptides and pharmaceutical intermediates. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for applications in drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral building block for the controlled incorporation of D-Histidine into peptide sequences.
• Pharmaceutical Intermediate: In the research and development of novel therapeutic peptides, including hormone analogs and enzyme inhibitors.
• Bioconjugation: For the site-specific modification of peptides and proteins in bioconjugate chemistry.
• Chemical Biology Research: As a tool compound for studying peptide structure-activity relationships (SAR) and receptor interactions.
• Process Development: For scaling up the production of peptide-based active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Product Name	D-Histidine(1-Trt)-Ome Hcl
CAS No.	200927-02-2
Molecular Formula	C30H31N3O2 • HCl
Molecular Weight	502.05 g/mol (Free base: 465.59)
Synonyms	D-Histidine(1-Trt)-OMe hydrochloride; (2R)-2-Amino-3-(1-trityl-1H-imidazol-4-yl)propanoic acid methyl ester hydrochloride; Methyl (2R)-2-amino-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoate hydrochloride; D-Histidine(1-Trt)-OMe HCl; Fmoc-D-His(Trt)-OH methyl ester hydrochloride (related precursor); D-Histidine(1-trityl)-methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our D-Histidine(1-Trt)-Ome Hcl is produced and tested to meet the stringent requirements of pharmaceutical R&D and cGMP manufacturing. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided, confirming compliance with specifications for assay, chiral purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.