Description

N(Tau)-Methyl-L-Histidine Hydrochloride is a high-purity, modified amino acid derivative of L-Histidine. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a specific biomarker and its potential in metabolic studies. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in advanced proteomics and metabolomics.

Application

• Biochemical Research: Used as a standard or reagent in studies of protein methylation, histidine metabolism, and enzyme function.
• Diagnostic Development: Serves as a critical reference standard or calibrator in LC-MS/MS methods for quantifying 3-methylhistidine, a biomarker for muscle protein breakdown.
• Pharmaceutical Intermediates: Acts as a key chiral building block or precursor in the synthesis of more complex bioactive molecules and potential drug candidates.
• Nutritional Science: Employed in metabolic pathway research related to amino acid utilization and studies on carnosine and related dipeptides.
• Proteomics & Metabolomics: Essential for method development and validation in high-throughput screening and biomarker discovery platforms.

Basic Information

Product Name	N(Tau)-Methyl-L-Histidine Hydrochloride
CAS No.	200926-96-1
Molecular Formula	C7H12N3O2 • HCl
Molecular Weight	219.65 g/mol
Synonyms	3-Methyl-L-histidine hydrochloride; L-3-Methylhistidine hydrochloride; Tau-methyl-L-histidine HCl; π-Methyl-L-histidine hydrochloride; (2S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid hydrochloride; 1-Methylhistidine hydrochloride; Hercynine hydrochloride
EINECS	Contact for details

Quality Control

Our N(Tau)-Methyl-L-Histidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements of research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.