Description

Boc-D-His(1-Me)-Oh is a protected, non-natural derivative of the amino acid histidine, specifically designed for advanced peptide synthesis. This compound is crucial for researchers and manufacturers requiring precise control over peptide structure and function, particularly in the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D teams and fine chemical suppliers engaged in the production of complex peptides, peptidomimetics, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for introducing a modified histidine residue with a protected imidazole side chain.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, hormones, and enzyme inhibitors.
• Peptidomimetic Design: Essential for creating stable analogs of natural peptides with enhanced metabolic stability or receptor selectivity.
• Bioconjugation: Serves as an intermediate for attaching peptides to other molecules, surfaces, or carriers.
• Chemical Biology Probes: Incorporated into peptides used to study protein-protein interactions and cellular signaling pathways.
• Fine Chemical Intermediate: Supplied to custom synthesis laboratories for the production of specialized amino acid derivatives and chiral compounds.

Basic Information

Product Name	Boc-D-His(1-Me)-Oh
CAS No.	200871-52-9
Molecular Formula	C12H19N3O4
Molecular Weight	269.30 g/mol
Synonyms	Boc-D-1-Methylhistidine; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(1-methyl-1H-imidazol-4-yl)propanoic acid; N-(tert-Butoxycarbonyl)-D-1-methylhistidine; Boc-D-1-Me-His-OH; D-1-Methylhistidine N-Boc derivative; tert-Butyloxycarbonyl-D-1-methylhistidine; Boc-D-His(1-Me)-OH; Nα-Boc-D-1-methylhistidine
EINECS	Contact for details

Quality Control

Our Boc-D-His(1-Me)-Oh is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.