Description

Z-D-Gln(Mtt)-Oh is a protected amino acid derivative, specifically the Z-protected form of D-glutamine with an Mtt (4-methyltrityl) side-chain protecting group. This compound is a critical building block in the solid-phase peptide synthesis (SPPS) of complex peptides, enabling the precise incorporation of D-glutamine residues. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools where chiral purity and side-chain protection are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of D-glutamine into peptide chains during Fmoc/t-Bu or Boc-based synthesis strategies.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including antimicrobial peptides (AMPs), hormone analogs, and targeted therapeutics.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides or peptide-protein conjugates for diagnostic and imaging applications.
• Chemical Biology Studies: Employed to investigate enzyme-substrate interactions, receptor binding, and the structure-activity relationships (SAR) of peptides.
• Process Development & Scale-Up: Supports the transition from laboratory-scale research to Good Manufacturing Practice (GMP) production of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Z-D-Gln(Mtt)-Oh
CAS No.	200716-85-4
Molecular Formula	C33H32N2O5
Molecular Weight	536.62 g/mol
Synonyms	Nα-Z-D-Glutamine(Mtt)-OH; Nα-Carbobenzoxy-D-glutamine(4-methyltrityl)-OH; Z-D-Glutamine(Mtt)-OH; (2R)-2-[[(Benzyloxy)carbonyl]amino]-5-[[tris(4-methylphenyl)methyl]amino]-5-oxopentanoic acid; Boc-D-Gln(Mtt)-OH (common alternate protection scheme); Fmoc-D-Gln(Mtt)-OH (common alternate protection scheme); D-Glutamine derivative, Nα-Z protected, side-chain Mtt protected; Peptide synthesis building block for D-Gln
EINECS	Contact for details

Quality Control

Every batch of Z-D-Gln(Mtt)-Oh is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive peptide synthesis applications. A Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and identity confirmation is supplied with each shipment. Specifications can be aligned with research-grade or cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.