Description

H-D-Gln(Mtt)-Oh CAS NO 200716-84-3 is a protected glutamine derivative, specifically an N-Mtt (4-methyltrityl) protected D-glutamine building block. This compound is critically important for the controlled synthesis of complex peptides, particularly in Solid-Phase Peptide Synthesis (SPPS), where it provides orthogonal protection for the glutamine side chain. It is an essential raw material for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the controlled, sequential assembly of peptides.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including hormones, enzyme inhibitors, and antimicrobial peptides.
• Bioconjugation and Labeling: The Mtt protecting group allows for selective deprotection, enabling site-specific modification or labeling of peptides.
• Combinatorial Chemistry: Employed in the generation of peptide libraries for high-throughput screening and drug discovery.
• Academic & Institutional Research: A fundamental reagent for studies in organic chemistry, medicinal chemistry, and chemical biology.
• Custom Peptide Service Providers: A critical raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	H-D-Gln(Mtt)-Oh
CAS No.	200716-84-3
Molecular Formula	C26H28N2O3
Molecular Weight	416.52 g/mol
Synonyms	D-Glutamine, N-[(4-methylphenyl)diphenylmethyl]-; H-D-Gln(Mtt)-OH; N-Mtt-D-glutamine; (R)-2-((((4-Methylphenyl)diphenylmethyl)amino)-5-aminopentanoic acid; N-4-Methyltrityl-D-glutamine; D-Glutamine, N-(4-methyltrityl)-; Fmoc-D-Gln(Mtt)-OH precursor; Protected D-Glutamine derivative
EINECS	Contact for details

Quality Control

Every batch of H-D-Gln(Mtt)-Oh is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting industry standards for peptide synthesis building blocks. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral integrity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.