Description

Fmoc-D-Gln-Opfp CAS NO 200622-33-9 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled incorporation of D-glutamine into peptide chains, enabling the research and development of novel peptides with enhanced stability and biological activity. It is an essential building block for pharmaceutical researchers, biotech companies, and CROs focused on peptide-based drug discovery, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential assembly of custom peptides, particularly for introducing the D-isomer of glutamine.
• Pharmaceutical R&D: Used in the discovery and development of therapeutic peptides, including antimicrobial peptides (AMPs), hormone analogs, and targeted drug conjugates.
• Peptide Library Production: Enables the creation of diverse peptide libraries for high-throughput screening in drug discovery campaigns.
• Bioconjugation and Probe Synthesis: Serves as a precursor for synthesizing peptide-based fluorescent probes, affinity tags, and imaging agents.
• Academic Research: Fundamental tool for studying peptide structure-activity relationships, enzyme-substrate interactions, and chiral effects in biological systems.
• Process Development: Employed in scaling up GMP-grade peptide APIs (Active Pharmaceutical Ingredients) for clinical and commercial manufacturing.

Basic Information

Product Name	Fmoc-D-Gln-Opfp
CAS No.	200622-33-9
Molecular Formula	C₂₆H₁₉F₅N₂O₆
Molecular Weight	550.44 g/mol
Synonyms	Fmoc-D-glutamine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-D-glutamine pentafluorophenyl ester; Fmoc-D-Glutamine-OPfp; Fmoc-D-Gln-OPfp; (2R)-5-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-[(2,3,4,5,6-pentafluorophenoxy)carbonylamino]-5-oxopentanoic acid; N-α-Fmoc-N-γ-trityl-D-glutamine pentafluorophenyl ester (related protected form); D-Glutamine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 2,3,4,5,6-pentafluorophenyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Gln-Opfp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.