Description

H-D-Glu-Otbu Hcl is a protected amino acid derivative, specifically the hydrochloride salt of H-D-Glutamic acid 1-tert-butyl ester. This high-purity building block is critical for the synthesis of complex peptides and active pharmaceutical ingredients (APIs) where precise stereochemistry and side-chain protection are required. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and development processes.

Application

• Peptide Synthesis: A key chiral building block for solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Used in the research and production of therapeutic peptides and peptidomimetics.
• Bioconjugation: Serves as a precursor for linking molecules in antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Employed in the study of enzyme-substrate interactions and protein structure-function relationships.
• Protecting Group Strategy: The tert-butyl ester group provides orthogonal protection for the glutamic acid side chain during multi-step syntheses.

Basic Information

Product Name	H-D-Glu-Otbu Hcl
CAS No.	200616-62-2
Molecular Formula	C9H18ClNO4
Molecular Weight	239.70 g/mol
Synonyms	H-D-Glutamic acid 1-tert-butyl ester hydrochloride; (2R)-2-Amino-5-(tert-butoxy)-5-oxopentanoic acid hydrochloride; D-Glutamic acid 5-tert-butyl ester hydrochloride; D-Glu(OtBu)-OH·HCl; Fmoc-D-Glu(OtBu)-OH precursor; Boc-D-Glu(OtBu)-OH deprotected intermediate; (R)-2-Amino-5-(tert-butoxy)-5-oxopentanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Glu-Otbu Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.