Description

Fmoc-Glu(o-2-Phipr)-Oh CAS NO 200616-39-3 is a specialized, side-chain protected derivative of glutamic acid, featuring the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group. This compound is critically important as a high-purity building block in solid-phase peptide synthesis (SPPS), enabling the precise and efficient construction of complex peptide sequences. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in the discovery and production of novel therapeutic peptides, peptide hormones, and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the automated, stepwise assembly of peptides on resin.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Serves as a precursor for introducing glutamic acid residues into peptides designed for conjugation with dyes, tags, or other molecules.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic Research: Employed in biochemical and structural biology studies investigating protein-protein interactions and enzyme mechanisms.
• Production of Biologically Active Peptides: Essential for synthesizing peptide fragments used in immunological studies, vaccine development, and as standards in analytical testing.

Basic Information

Product Name	Fmoc-Glu(o-2-Phipr)-Oh
CAS No.	200616-39-3
Molecular Formula	C31H33NO6
Molecular Weight	515.60 g/mol
Synonyms	Fmoc-Glu(O-2-phenylisopropyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2-phenylpropan-2-yl)-L-glutamic acid; Fmoc-L-glutamic acid 2-phenylisopropyl ester; Fmoc-Glu(OtBu)-OH analog (protected form); Fmoc-Glu(O-2-Ph-iPr)-OH; Protected Fmoc-glutamic acid derivative; Peptide synthesis building block 200616-39-3
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(o-2-Phipr)-Oh is manufactured under strict quality management systems to ensure the high purity and consistency required for sensitive peptide synthesis applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing specific results for identity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and prevent decomposition. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.