Description

Fmoc-D-Cys(Mob)-Oh CAS NO 200354-43-4 is a high-purity, orthogonally protected D-cysteine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters for its critical role in constructing complex peptides and peptidomimetics, where it enables the precise, sequential introduction of cysteine residues with controlled side-chain deprotection. Pharmaceutical researchers, biotech companies, and CROs specializing in therapeutic peptide development need this building block to create stable disulfide bridges and incorporate thiol functionalities into novel drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides containing D-cysteine.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including hormones, antimicrobial peptides, and targeted therapeutics.
• Disulfide Bridge Engineering: Enables the controlled formation of intramolecular and intermolecular disulfide bonds, which are crucial for the structural stability and biological activity of many peptides.
• Peptidomimetic & Conjugate Synthesis: Serves as a precursor for creating peptide-drug conjugates (PDCs) or labeled peptides where the thiol group is used for site-specific modifications.
• Chemical Biology & Proteomics Research: Employed in studies involving protein folding, protein-protein interactions, and the development of activity-based probes.
• GMP Manufacturing of APIs: Suitable for use in the current Good Manufacturing Practice (cGMP) production of peptide active pharmaceutical ingredients (APIs) for clinical trials and commercial supply.

Basic Information

Item	Detail
Product Name	Fmoc-D-Cys(Mob)-Oh
CAS No.	200354-43-4
Molecular Formula	C25H23NO5S
Molecular Weight	449.52 g/mol
Synonyms	Fmoc-D-Cys(Mob)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-cysteine 4-methoxybenzyl ester; Fmoc-D-cysteine(Mob)-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((4-methoxybenzyl)thio)propanoic acid; Fmoc-D-Cys(4-MeOBzl)-OH; Fmoc-D-Cysteine(Mob)-OH; N-Fmoc-S-(4-methoxybenzyl)-D-cysteine; Fmoc-D-Cys(Mob)
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-Cys(Mob)-Oh undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for peptide synthesis. Our standard quality commitment includes comprehensive analysis by HPLC, NMR, and mass spectrometry to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory standards, including those for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions, moisture, or light may lead to decomposition and reduced performance. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.