Description

Fmoc-D-Cys(Mbzl)-Oh is a high-purity, non-natural amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for introducing the D-cysteine residue with a 4-methoxybenzyl (Mbzl) thiol protecting group into complex peptide chains, enabling the controlled formation of disulfide bonds. It is an essential building block for pharmaceutical researchers and manufacturers developing therapeutic peptides, peptide-based diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of peptides, particularly those requiring D-cysteine incorporation.
• Therapeutic Peptide Development: Used in the research and GMP-scale production of peptide drugs where precise stereochemistry and disulfide bridge formation are crucial for bioactivity and stability.
• Peptide Library Construction: Enables the creation of diverse peptide libraries for drug discovery, screening, and structure-activity relationship (SAR) studies.
• Bioconjugation and Protein Engineering: Serves as a specialized precursor for site-specific labeling or modification of peptides and proteins via its protected thiol group.
• Biochemical Research: A vital reagent for academic and industrial research into peptide structure, function, and folding mechanisms.

Basic Information

Product Name	Fmoc-D-Cys(Mbzl)-Oh
CAS No.	200354-41-2
Molecular Formula	C26H25NO5S
Molecular Weight	463.55 g/mol
Synonyms	Fmoc-D-cysteine(4-methoxybenzyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-cysteine 4-methoxybenzyl ester; Fmoc-D-Cys(Mob)-OH; Fmoc-D-Cysteine(Mbzl)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((4-methoxybenzyl)thio)propanoic acid; N-Fmoc-S-(4-methoxybenzyl)-D-cysteine; Fmoc-D-Cys(pMeOBzl)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Cys(Mbzl)-Oh is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation, to ensure it meets the exacting standards required for peptide synthesis. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.5%
Optical Rotation	[α]D20: Specific range provided on COA
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.