Description

Fmoc-Asn(Mtt)-Opfp is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for enabling the precise, sequential construction of complex peptides and proteins, particularly those containing sensitive asparagine residues. It is an essential building block for researchers and manufacturers in pharmaceutical development, biotechnology, and academic research, facilitating the production of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/t-Bu strategy, allowing for the controlled incorporation of asparagine.
• Synthesis of Complex Peptides: Enables the construction of peptides with challenging sequences, including those prone to side reactions.
• Pharmaceutical Intermediate: Serves as a critical precursor in the research and development of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Used in the preparation of peptide conjugates for drug delivery systems or diagnostic probes.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Glycopeptide Synthesis: The Mtt (4-methyltrityl) protecting group on the asparagine side chain is selectively removable, allowing for subsequent glycosylation.

Basic Information

Product Name	Fmoc-Asn(Mtt)-Opfp
CAS No.	200259-55-8
Molecular Formula	C48H38F5N3O6
Molecular Weight	847.83 g/mol
Synonyms	N-α-Fmoc-N-γ-Mtt-L-asparagine pentafluorophenyl ester; Fmoc-L-asparagine(Mtt)-OPfp ester; Fmoc-Asn(Mtt)-OPfp; N-(9-Fluorenylmethoxycarbonyl)-N'-(4-methyltrityl)-L-asparagine pentafluorophenyl ester; Fmoc-Asn(Mtt)-O-Pfp; Fmoc-Asparagine(Mtt)-OPfp
EINECS	Contact for details

Quality Control

Our Fmoc-Asn(Mtt)-Opfp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR, and mass spectrometry for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducibility and reliability in your research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.