Description

H-D-Asn(Mtt)-Oh is a protected amino acid derivative, specifically an asparagine residue with a 4-methyltrityl (Mtt) protecting group on the side chain amide nitrogen. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of asparagine residues during Fmoc/t-Bu chemistry.
• Therapeutic Peptide Production: Used in the research and GMP manufacturing of peptide-based pharmaceuticals targeting metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Labeling: The selectively removable Mtt group allows for the site-specific modification of peptides with fluorophores, tags, or other functional molecules.
• Combinatorial Chemistry: Serves as a building block in libraries for drug discovery and structure-activity relationship (SAR) studies.
• Biochemical Research: Employed in academic and industrial labs for studying protein-protein interactions, enzyme substrates, and receptor ligands.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the synthesis of peptide linkers used to connect cytotoxic drugs to monoclonal antibodies.

Basic Information

Product Name	H-D-Asn(Mtt)-Oh
CAS No.	200203-23-2
Molecular Formula	C31H30N2O3
Molecular Weight	478.58 g/mol
Synonyms	H-Asparagine(Mtt)-OH; Fmoc-Asn(Mtt)-OH (common precursor); Nδ-(4-Methyltrityl)-L-asparagine; (2S)-2-Amino-3-[[[4-methylphenyl)diphenylmethyl]amino]-3-oxopropanoic acid; D-Asn(Mtt)-OH; Asparagine, Nδ-(4-methyltrityl)-; Protected Asparagine Derivative; Mtt-Asn-OH
EINECS	Contact for details

Quality Control

Our H-D-Asn(Mtt)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for peptide synthesis intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, reporting key parameters such as assay (HPLC), chiral purity, and residual solvent content. We support compliance with cGMP, ISO, and other relevant regulatory frameworks for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.