Description

Fmoc-D-Arg(Pmc)-Opfp is a protected amino acid derivative, specifically the pentafluorophenyl (Opfp) ester of Fmoc-D-arginine with side-chain protection by 2,2,5,7,8-pentamethylchroman-6-sulfonyl (Pmc). This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and racemization-free incorporation of D-arginine into complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary reagent for the automated or manual synthesis of peptides containing D-arginine residues.
• Pharmaceutical Research: Key intermediate in the development of novel peptide-based drugs, including antimicrobial peptides and hormone analogs.
• Peptidomimetic Design: Used to create stable, non-natural peptide analogs with enhanced biological activity and metabolic stability.
• Bioconjugation: Serves as a reactive handle for labeling or attaching peptides to other molecules, surfaces, or carriers.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial R&D: Fundamental tool for studying protein-protein interactions, enzyme substrates, and receptor ligands.

Basic Information

Product Name	Fmoc-D-Arg(Pmc)-Opfp
CAS No.	200188-07-4
Molecular Formula	C₄₀H₄₀F₅N₅O₇S
Molecular Weight	821.84 g/mol
Synonyms	Fmoc-D-arginine(Pmc)-OPfp pentafluorophenyl ester; N-α-Fmoc-N-ω-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-D-arginine pentafluorophenyl ester; Fmoc-D-Arg(Pmc)-O-Pfp; Fmoc-D-Arg(Pmc)-OPfp; Pentafluorophenyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-ω-[(2,2,5,7,8-pentamethyl-3,4-dihydro-2H-1-benzopyran-6-yl)sulfonyl]-D-argininate; Fmoc-D-Arg(Pmc)-OPfp ester; Fmoc-D-Arg(Pmc)-OPfp CAS 200188-07-4
EINECS	Contact for details

Quality Control

Our Fmoc-D-Arg(Pmc)-Opfp is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive peptide synthesis applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, desiccate at low temperature.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.