Description

Boc-Arg(Pbf)-Oh is a protected derivative of the amino acid L-arginine, widely used as a key building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily utilized by the pharmaceutical, biotechnology, and research sectors for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the controlled incorporation of arginine residues into peptide chains.
• Therapeutic Peptide Production: Used in the research and GMP manufacturing of peptide-based drugs targeting various diseases.
• Bioconjugation and Labeling: Serves as a precursor for creating labeled peptides for diagnostic imaging or biochemical assays.
• Research & Development: Critical for academic and industrial R&D in medicinal chemistry, proteomics, and chemical biology.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for drug discovery screening.

Basic Information

Product Name	Boc-Arg(Pbf)-Oh
CAS No.	200124-22-7
Molecular Formula	C23H37N5O7S
Molecular Weight	527.64 g/mol
Synonyms	Nα-Boc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine; Boc-L-arginine(Pbf)-OH; tert-Butyloxycarbonyl-L-arginine(Pbf)-OH; Boc-Arg(Pbf)-OH; N-α-Boc-N-ω-Pbf-L-arginine; (2S)-5-[[(2,2,4,6,7-Pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid; L-Arginine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]-
EINECS	Contact for details

Quality Control

Our Boc-Arg(Pbf)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can provide material traceable to relevant standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	-10.0° to -14.0° (c=1 in DMF)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.