Description

1,6,7,8,9,9A-Hexahydro-6-Methyl-4-Oxo-4H-Pyrido[1,2-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex fused-ring structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for developing next-generation drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting the central nervous system or possessing anti-inflammatory properties.
• Organic Synthesis Building Block: Utilized in research and development for constructing novel heterocyclic compounds due to its reactive ester and ketone functional groups.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies in the discovery of new pharmacologically active agents.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals requiring a high degree of molecular complexity and purity.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	1,6,7,8,9,9A-Hexahydro-6-Methyl-4-Oxo-4H-Pyrido[1,2-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester
CAS No.	29766-64-1
Molecular Formula	C13H18N2O3
Molecular Weight	250.29 g/mol
Synonyms	Ethyl 1,6,7,8,9,9a-hexahydro-6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate; 4H-Pyrido[1,2-a]pyrimidine-3-carboxylic acid, 1,6,7,8,9,9a-hexahydro-6-methyl-4-oxo-, ethyl ester; Ethyl 6-methyl-4-oxo-1,4,6,7,8,9-hexahydropyrido[1,2-a]pyrimidine-3-carboxylate; 29766-64-1; Pyrido[1,2-a]pyrimidine derivative; Hexahydro-6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Quality is verified through comprehensive analytical methods including HPLC, GC, and NMR to confirm identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support development projects requiring compliance with ICH guidelines and can tailor purity grades to meet specific project phases, from research to pre-clinical.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.