Description

H-α-Me-D-Leu-Oh is a non-natural, chiral amino acid derivative, specifically the D-isomer of α-methyl leucine. This compound serves as a critical building block (synthon) in advanced organic synthesis, particularly for introducing steric hindrance and modifying peptide backbone properties. It is essential for research and production in the pharmaceutical and biotechnology sectors, where it is used to develop novel therapeutic peptides, protease inhibitors, and chiral catalysts.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in research to create inhibitors for enzymes like HIV protease, leveraging its non-natural, sterically hindered structure.
• Peptidomimetics: Incorporation into peptide analogs to enhance metabolic stability, bioavailability, and receptor selectivity.
• Chiral Auxiliary/Synthon: Employed in asymmetric synthesis to induce chirality in target molecules.
• Biochemical Research: Tool compound for studying enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Material Science: Potential monomer for synthesizing specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	H-α-Me-D-Leu-Oh
CAS No.	29589-03-5
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	(R)-2-Amino-4-methyl-2-pentanoic acid; D-α-Methylleucine; (R)-2-Amino-4-methylpentanoic acid, 2-methyl derivative; D-2-Amino-4-methyl-2-pentanoic acid; H-D-α-Me-Leu-OH; D-2-Methylleucine; (2R)-2-Amino-4-methyl-2-pentanoic acid; D-α-Methyl-leucine
EINECS	Contact for details

Quality Control

Our H-α-Me-D-Leu-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.