Description

10-Formyltetrahydropteroyl-γ-Glutamylglutamic Acid CAS NO 29552-62-3 is a specialized folate derivative and a key biochemical intermediate in one-carbon metabolism. This compound is of significant interest for research and development in advanced pharmaceutical synthesis and metabolic studies. It is primarily utilized by researchers and manufacturers in the life sciences sector, particularly those focused on oncology, neurology, and the development of novel therapeutic agents targeting folate-dependent pathways.

Application

• Biochemical Research: Critical intermediate for studying enzymatic mechanisms in folate metabolism and one-carbon transfer reactions.
• Pharmaceutical Reference Standard: Used as a high-purity standard for analytical method development and quality control in drug manufacturing.
• Precursor Synthesis: Serves as a key building block in the synthesis of more complex folate analogs and antifolate drugs.
• Enzyme Inhibition Studies: Employed in research to investigate the inhibition of dihydrofolate reductase (DHFR) and other folate pathway enzymes.
• Cell Culture & Microbiology: Used in specialized media formulations for studying microbial and mammalian cell growth under controlled folate conditions.
• Diagnostic Development: Potential use in the development of diagnostic assays for measuring folate levels and related metabolic disorders.

Basic Information

Product Name	10-Formyltetrahydropteroyl-γ-Glutamylglutamic Acid
CAS No.	29552-62-3
Molecular Formula	C26H32N8O11
Molecular Weight	632.58 g/mol
Synonyms	10-Formyltetrahydrofolyl-γ-glutamylglutamate; 10-Formyl-THF-Glu-Glu; 10-Formyl-5,6,7,8-tetrahydropteroyl-γ-glutamylglutamic Acid; 10-CHO-THF-Glu2; NSC 139490; Folate Derivative; 10-Formyltetrahydropteroyl diglutamate; 10-Formyl-H4PteGlu2
EINECS	Contact for details

Quality Control

Our 10-Formyltetrahydropteroyl-γ-Glutamylglutamic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in basic aqueous solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.